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Ncardia Workshop 2017

We were proud to host first Ncardia Application Workshop, November 29 - December 1st, 2017. Thanks again to all the attendees and the speakers for your participation and for making this workshop an exciting event.

You can check out and download the presentations and posters below

(Note: this page is updated continously and downloads will be added upon availability)

Final Agenda:

(download pdf version here)

Wednesday, November 29

12:00 PM

Arrival at Ncardia/ BioCampus - LUNCH

1:00 PM

Stefan Braam, PhD (Ncardia)
"Stem Cell Based Products and Services for Drug Discovery & Development"

1:25 PM

Prof. Michael Schneider, PhD, MD (Imperial College London)
MAP4K4 mediates human cardiac muscle cell death: Human pluripotent stem cell-derived cardiomyocytes for target validation and drug development” 

1:55 PM

Mohamed Kreir, PhD (Janssen Pharmaceutica)
“In vitro cell-based assays to predict drug-induced seizure liability using hiPSC derived neurons” 

2:20 PM

Ryan McGarrigle, PhD (Luxcel Biosciences) 
Cardiomyocyte function characterised through combined analysis of metabolic flux, beat rate and cellular oxygenation and its application in vitro ischemia reperfusion modelling

2:45 PM

Coffee break

3:30 PM

Live Demonstrations

7:00 PM

Dinner

 

Thursday, November 30

8:45 AM

Arrival at Ncardia/ BioCampus

9:00 AM

Said El Haou, PhD (Metrion)
Validating human iPSC cardiomyocytes for CiPA cardiac safety testing – from electrophysiology to phenotypic assays

9:25 AM

Mark Bryant, PhD (Clyde Biosciences)
”Optical measurements of electrical mechanical function of Cor.4U cells using CellOPTIQ”

9:50 AM

Stephane Bedut, PhD (Scientific service provider in site at VWR Catalyst)
High throughput optical recording of voltage and calcium signals of human ips-derived cardiomyocytes for drug screening and cell lines charcterization” 

10:15 AM

Coffee Break

10:45 AM

Silvia Cainarca, PhD (Axxam)
iPSC-derived cells going high throughput: new strategies for ion channels drug discovery

11:10 AM

Christian Holz (Molecular Devices)
“Phenotypic assays for compound effects using imaging-based morphological characterization of 3D neuronal cultures and calcium transients in beating cardiomyocytes”

11:35 AM

Linn Schneider, PhD (Bayer HealthCare) & Benjamin Wolters, PhD (Ncardia)
Opening the optogenetic toolbox for iPSC-derived Cardiomyocytes” 

12:00 PM

Lunch Break

1:00 PM

Prof. Christine L. Mummery, PhD (Leiden University Medical Center)

KEYNOTE: “Advancing disease modeling using hiPSC

1:40 PM

Caroline Archer, PhD (AstraZeneca)
Validation and Utility of Human iPS-Vascular Smooth Muscle Cells as an in vitro Vascular Model

2:05 PM

Prof. Philipp Sasse, PhD (University of Bonn) 
The enlightened heart: Optogenetic methods to investigate and treat cardiac arrhythmia

2:30 PM

Elena Dragicevic, PhD (Nanion Technologies)
HTS automated patch clamptakes cardiac safety testing to the next level”

 

Coffee Break

3:30 PM

Live Demonstrations

4:45 PM

Shuttle Bus to Hotel

  

Friday, December 1

8:45 AM Arrival at Ncardia/ BioCampus 
 
9:00 AM

Thomas Licher, PhD (Sanofi) 
“"High throughput assay applications with iPSC-derived cardiomyocytes: Ca2+osscilations and beyond”

9:25 AM

Georg Rast, PhD (Boehringer Ingelheim) 
“hiPSC-Derived Cardiomyocytes: Diversity In A Dish"

9:50 AM

Tessa de Korte (Ncardia)
Multiparametric assessment of the effects of chemotherapeutic drugs on the (electro)physiology of Pluricyte

10:10 AM Coffee Break
 
10:40 AM

Live Demonstrations

12:00 AM

Departure

  

Live Demonstrations:

  • Fatty acid metabolism / oxygen consumption rate (OCR) - Luxcel/BMG Labtech 
  • Cardiac contractile force measurement
  • HTS calcium / voltage sensitive dyes - Hamamatsu (FDSS)
  • MEA + optogenetics - Axion (Maestro + Lumos + Xpress.4U)
  • Impedance + optogenetics- Nanion (CardioExcyte96 +Sol + Xpress.4U)
  • Impedance /+MEA - Acea (xCELLigence RTCA Cardio /ECR)

 

Posters:

  1. Multiparametric Assessment of Cardiotoxicity of Chemotherapeutic Drugs in Human Induced Pluri- potent Stem Cell (hiPSC)-derived Cardiomyocytes (Ncardia)
  2. Cytotoxicity Monitoring For Safety Assessments: iPSC Cardiomyocytes and More (Nanion Technologies)
  3. Cardiotoxic Classification of 85 Compounds Based On Statistical Learning Applied To Impedance Responses - (Cybernano)
  4. High-Throughput Pharmacology of Cardiac L-type Ca2+ Channels in Overexpressing Cell Lines and iPSC-Cardiomyocytes - (Nanion technologies)
  5. Application of Human-Induced Pluripotent Stem Cell Derived Cardiomyocytes in High-Throughput Screening Assays for Drug Safety and Efficacy Testing - (Ncardia/ Hamamatsu Photonics)
  6. Coupled Impedance & Field Potential Data Analysis of in vitro Cardiomyocyte Assays - (Cybernano)
  7. Towards Prediction of Acute and Chronic Drug Effects using Multi-parameter Profiling of hiPSC-derived Cardiomyocytes - (Ncardia)
  8. Studying Inotropic Compound Effects in Relatively Mature Human iPSC-derived Cardiomyocytes using 2D and 3D Models - (Ncardia, University Medical Center Hamburg-Eppendorf, University Nottingham)
  9. A Data-Driven Modeling Method to Analyze Cardiomyocyte Impedance Data - (Cybernano)
  10. Development of Native Neuron and iPSC-derived Electrophysiology Assays for Neurotoxicology Scree- ning and Translational Drug Discovery - (Metrion Biosciences)
  11. High-Content Assay for Morphological Characterization of Neuronal Development in 3D Matrix Using Human iPSC-derived Neuronal Cultures - (Molecular Devices, LLC;Laboratory of Biosensors and Bioelectronics, ETH Zurich; Ncardia; Ectica Technologies)
  12. Comparison of Compression Solutions for Impedance and Field Potential Signals of Cardiomyocytes - (Cybernano)
  13. CardioExcyte 96 meets CellDrum - True Contractility in High Performance - (InnoVitro, Nanion Technology, University Aachen)
  14. Unblinded: Responses to CiPA 28 Compounds in Cor.4U Cardiomyocytes - (Ncardia)
  15. CardioExcyte 96 CiPA Study Recordings with Different iPSC-derived Cardiomyocytes - (Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Ro- che, Ltd - Drug Disposition & Safety)
  16. Neurotransmitter Screening via Dynamic Calcium Flux and MEA-based Seizure Liability Assessment in Human iPS Neurons - (Ncardia)
  17. Opening the Molecular Toolbox: Co-transfection Of KCNJ2 and Channelrhodopsin2 mRNAs for Precise Control of iPS-Cardiomyocyte Pacing and Functionality - (Ncardia, IonsGate)
  18. Antiarrhythmic Effects of Carvedilol and Flecainide in Cardiomyocytes Derived From Catecholaminer- gic Polymorphic Ventricular Tachycardia Patients - (University of Tampere, Tampere, Finland; Helsinki University Central Hospital, Helsinki, Finland; Heart Center, Tampere University Hospital, Tampere)
  19. Comparison of Compression Solutions for Impedance and Field Potential Signals of Cardiomyocytes - (Cybernano)
  20. Modifications of Stem Cell-Derived Cardiomyocytes Using Non-Integrating RNA: Applications for Optogenetics, siRNA Knockdown and Dominant Negative Expression of Mutated Transcripts - (Ncardia, IonsGate)
  21. Characterization of Human iPSC-derived Cardiomyocytes (Cor.4U®) on an Automated Planar Patch Clamp Set Up (QPatch) - (Sophion Biosciences)

The workshop took place at the BioCampus in Cologne from November 29 - December 01, 2017

 

 

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