Our expert for hiPSC-derived cardiac cells, as well as cell-based assays & services for drug safety and efficacy screenings
Human iPSC-derived cardiomyocytes utilization with the FDSS/µCell instrument has been optimized. Combining these technologies enables the evaluation of potential cardiotoxic effects of compounds at high-throughput (up to 384 wells), thereby supporting your decision making in the safety of drug candidates at an early stage of drug development.
You can find a step-by-step description of the analysis of fluorescent dye-based calcium transients of our hiPSC-derived cardiomyocytes using the FDSS/µCell System in our User Guide:
Case studies were performed to assess the acute effects of well-known cardioactive compounds in Pluricyte® Cardiomyocytes calcium transients using the FDSS/µCELL kinetic plate reader. Acute effects of cardioactive compounds were determined to analyze various parameters, including peak frequency, peak amplitudes, peak slopes, and average peak width duration.
You can find the complete study in our application note: