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Case studies were performed to assess the effects of cardioactive compounds on the electrophysiology of Pluricyte® Cardiomyocytes using the Multiwell-MEA-System (Multi Channel Systems). The effects of cardioactive reference compounds on the field potential duration, beat period, depolarization peak and conduction velocity are shown here.
Dofetilide induced a concentration-dependent increase of the field potential duration in Pluricyte® Cardiomyocytes
Dofetilide is a hERG channel blocker that is expected to prolong the repolarization, resulting in prolonged field potential duration (FPD) and ultimately proarrhythmic events. The induced concentration-dependent increase of the FPD in Pluricyte® Cardiomyocytes is shown here (first panel). At 100 nM, arrhythmias were observed (second panel).
You can find the complete study in our application note: