Impedance assay

Our scientists assess endothelial permeability through impedance assays. This allows for monitoring of a wide range of physiological and pathophysiological mechanisms for drug discovery, to assess both compound safety and efficacy. Compared to other endothelial permeability assay types, like transwells, electrical impedance is more sensitive, and enables time-lapse tracking.

Our advanced data analysis capabilities enable calculation of time course changes in cell permeability, cell-matrix interaction and the cell membrane capacitance. Such analyses enable discrimination between necrosis and apoptosis and between subtle loss of cell-cell contacts or acute cell death.

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