Impedance and impedance-based assays monitor cell morphological changes in a label-free and real-time manner. Such assays enable monitoring of a wide range of physiological and pathophysiological mechanisms in model systems used in drug discovery. These comprise for instance the assessment of cardiomyocyte contractility in particular disease models as well as in cardiac drug safety, but also in-depth analysis of vascular barrier function in health and disease.

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Vascular permeability

Vascular endothelial cells cover the inner parts of the vascular system and play an intricate role in for example regulation of vascular tone and the supply of nutrients to the tissue environment. Disturbance of the endothelial barrier contributes to the development of many diseases, including inflammation and stroke, and can also be caused by drugs. Assessing the barrier function of hiPSC-derived endothelial cells over time is very instrumental to assess drug induced vascular leakage.

hiPSC-derived endothelial cells were cultured for 7 days in a 96-well ECIS plate (Applied Biophysics) and barrier resistance was followed over time demonstrating vascular leakage by increased concentrations of thrombin.

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