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Process engineer iPSC-based cell manufacture

Leiden, The Netherlands

Ncardia is an established, globally operating, stem cell-based drug discovery company, based on the belief that human induced pluripotent stem cell (iPSC) technology will help get better therapies to patients faster. We are a leader in contract research, development and manufacture of iPSC-based solutions for early and preclinical drug discovery: our goal is to enable pharmaceutical and therapeutic development companies to make more confident decisions in therapeutic discovery and development by integrating iPSC technologies into their drug development processes.

We are an enthusiastic, skilled, and committed international team in which everyone can make a decisive contribution. Within our Discovery Services team in Leiden (The Netherlands) there is a position immediately available for a Process Engineer iPSC-based cell manufacture.

Job Description

This is a highly collaborative role in the Manufacturing Technology department. You will work in a multidisciplinary, international team of world-class scientists with state-of-the-art knowledge of stem-cell differentiation biology. As a process engineer your key responsibilities will be in developing suspension-based and/or adherent culture processes for the manufacturing of various cell types from pluripotent cells, at scale.

You are self-motivated and energetic with a strong focus on innovation and critical thinking. You have experience in a service organization or demonstrable soft skills that are needed for commercial projects with customers. As part of the job responsibility includes hands-on processes development, the preferred candidate is a motivated researcher with desire to work in a laboratory, including occasional cell maintenance during the weekend.

Responsibilities

  • Design and perform process engineering studies focused on scale-up of novel hiPSC-derived cell types according to defined timelines, budget, and milestones. Customer sponsored projects are part of the position.

  • Evaluate and implement technologies to improve consistency, increase scale, and facilitate cGMP compliance of bioprocesses for manufacturing iPSC-derived cells.

  • Develop scale-down models for process optimization studies.

  • Evaluate and implement process analytical technologies (PAT) for improved monitoring and control of stem cell bioprocesses.

  • Ensure accurate internal data reporting.

  • Contribute to or lead scientific presentations and collaboration with internal and external stakeholders.

  • Write protocols, technical reports, and Standard Operating Procedures (SOPs).

  • Collaborate across project teams to integrate processes.

  • Participate in technology transfer of processes and equipment to another department or client facility.

Qualifications

  • Ph.D. in biology, bio-engineering, or other relevant discipline and/or relevant equivalent working experience.

  • Demonstrated proficiency in mammalian cell culture processes - preferably with controlled bioreactors.

  • Relevant experience or understanding of the following: Process development as a member of product/process development teams, QbD/DOE approaches, Pluripotent stem cells and/or differentiation, cGMP biomanufacturing.

  • Attention to detail, and problem-solving.

  • Excellent organization, project, and time management skills. Timelines may be demanding.

  • Capacity to innovate and contribute to company IP.

  • Good communicator and team-player.

  • Can maintain flexibility in a dynamic environment.

  • Proficiency in English, both written and spoken.

We offer a challenging position in a dynamic biotech company with room for personal growth and development. Depending on your education and experience, we provide an appropriate salary.

Position Type

Full-Time

Start Date

Immediately

Interested?

Send your motivation letter with curriculum vitae to: careers@ncardia.com