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"A standardized and scalable angiogenesis assay using iPSC-derived endothelial cells enabling phenotypic screening in cardiovascular drug discovery"

presented at the ELRIG 2019 meeting in Liverpool

 

 

Abstract: To meet the demands of predictive preclinical vascular drug research, improved in vitro models of the vasculature are required: assays that are amenable to high-throughput screening, with a scalable and robust cell source, in a physiological relevant cellular micro-environment. We have developed a reproducible manufacturing process for the generation of large numbers of iPSC-ECs (>90% CD31+) using a set of controlled bioreactor systems and subjected the cells to a standardized microfluidic cell culture platform to develop an angiogenesis assay which is compatible with high-content imaging and high-throughput screening.

 

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