Developing hiPSC-derived cardiac and neuronal disease models of your choice
The utility of a cell-based disease model relies upon generation of a demonstrable phenotype that closely reflects the underlying biology of the disease. We develop human iPSC-derived cardiac and neuronal disease models of your choice, depending on your requirements to enable target or phenotypic drug discovery, as well as guiding structure-activity relationship (SAR) studies.
Patient-derived: Cardiomyocytes bearing physiologically relevant functional phenotypes can be generated from an individual with a genetic, ethnic or disease background.
Induced: Disease phenotypes can be induced in "healthy" cells through utilization of disease-relevant stimuli.
CRISPR-edited: Targeted CRISPR/Cas9 gene editing enables the rapid creation of cell lines containing disease-associated mutations.