Cardiovascular Safety & Toxicity Evaluation Services

Assessment of drug safety and toxicity is complex and can be time consuming. Cardiac toxicity may be observed after short or long-term compound exposure. Additionally, structural and functional aspects of cardiac toxicity need to be considered. Uncovering potential cardiotoxic effects of drug candidates earlier in the drug discovery process will decrease drug attrition rates and saves needed resources. Ncardia provides integrated cardiovascular services to enhance the assessment of cardiac safety and toxicity of drug candidates. All services utilize functional human iPSC-derived cell models in qualified assays.

Safety Services


Acute Cardiac Safety - MEA Analysis

Delivers an acute cardiac safety profile of your compounds following the current protocols of the CiPA initiative for microelectrode arrays (MEA) analysis.


Cell Viability and Health - Impedance Analysis

Provides an acute and long-term cardiac safety profile based on label-free impedance analysis of your compounds using hiPSC-derived cardiomyocytes.


Contractility - Impedance Analysis

Provides true force measurement to study the effect of drug candidates on the contractility and force-frequency relationships of hiPSC-derived cardiomyocyte.


Structural Cardiotoxicity - Troponin Detection

Delivers a structural cardiotoxicity profile of your compounds based on the detection of cardiac specific biomarkers like Troponin I release by hiPSC-derived cardiomyocytes.



Cell Viability and Health - Endothelial Barrier Toxicity

Assessment of drug-induced vascular leakage using high-content, real-time and label-free impedance-based technology that monitors changes in electrical impedance across the endothelial cell monolayer.


Calcium Transients - Calcium Imaging

High-throughput screening of compound effects on cardiomyocyte electrophysiology by analyzing the intracellular calcium transients.


Multiparametric Functional & Structural Cardiotoxicity

An analysis by impedance (contractility), electrophysiology and biomarker release (structural).