"Reproducible and large-scale generation of high-quality and functional human iPSC-derived CNS cells"
Isabel Onofre, PhD
The development of physiologically relevant human models for neurological diseases remains a challenge for pre-clinical drug discovery. With the emergence of human induced pluripotent stem cell (hiPSC) technology, it is now possible to design and manufacture cell types that are critical players in neural disease pathogenesis, such as neurons, astrocytes and microglia. These hiPSC-derivatives retain their patient-specific genetic backgrounds and demonstrate clinically relevant phenotypes. They, therefore, can serve as human in vitro platforms to accelerate the drug development pipeline. A first challenge to implementing hiPSCs for drug discovery is the reproducible and large-scale generation of high quality and functional differentiated derivatives. During this webinar we will discuss the advantages and challenges of manufacturing and co-culturing hiPSC-derived neuronal models for disease modeling, assay development and drug testing purposes.
In this webinar you will learn:
- The benefits of using hiPSC-derived neuronal models for drug discovery
- Key considerations for the large-scale generation of functional human iPSC-derived neuronal cells
- Insights into co-culturing possibilities of hiPSC-derived neurons, astrocytes and microglia.