Ncardia developed a human iPSC-derived dopaminergic neuron model to capture the key pathological hallmarks of Parkinson’s disease (PD), providing a robust platform for screening potential therapeutics and studying disease mechanisms in vitro.
This poster offers an inside look, detailing:
- How Ncardia’s iPSC-derived dopaminergic neurons replicate α-synuclein (SNCA) pathology and enable assessment of neurodegenerative phenotypes
- High-content imaging and electrophysiology data revealing mitochondrial dysfunction, disrupted proteasomal activity and neuronal network changes
- Insights into how PD-relevant phenotypes can be rescued with pharmacological intervention (e.g., rapamycin)
- Quantitative assays assessing cellular and functional readouts
Download the Poster