By combining automated workflows with physiologically relevant human models, Ncardia’s innovative iPSC-based platforms offer a more predictive, scalable and efficient approach to RNA therapeutic development.
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- How Ncardia’s automated RT-qPCR assay achieves high reproducibility in antisense oligonucleotide (ASO) screening across multiple iPSC-derived cell types
- Use of hiPSC-derived cortical neurons and CNS cultures to assess both target knockdown and dose-dependent neurotoxicity
- Functional insights from calcium transient and MEA assays identifying neuronal excitability and network disruptions
- How these assays enable early, human-relevant predictions of in vivo toxicity, reducing animal use and improving translational confidence
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