47 Rue Adrienne Bolland
Peripheral neurons play an important role in transmitting signals between the periphery and the central nervous system. They are valuable models for use in drug development. Applications include functional and general neurotoxicity assays (e.g., peripheral neuropathy) as well as for botulinum N toxin tests to be used in cosmetic applications in humans.
Peripheral neurons are positive for the neuronal marker MAP2 (red). Nuclei stained with Hoechst (blue).
Peripheral neurons reveal significant TTX-sensitive inward currents and at least two types of outward currents in voltage-clamp mode (A, B). Current injection elicits primary-like action potentials (C ). A subset of peripheral neurons exhibits spontaneous activity in current clamp mode (D).
Peripheral demonstrate clear detectable burst-like activity. Lot 1 (left) and Lot 2 (right) show high and comparable activity after 6 days in culture on microelectrode array. The heatmap shows a 120 sec signal overlay.