Human iPSC-derived Cardiomyocytes

Familial, idiopathic and drug-induced cardiovascular diseases are leading causes of mortality worldwide. Therefore, it is of great importance to increase our understanding of underlying pathophysiology mechanisms in order to develop effective treatments. hiPSC-derived cardiomyocytes can be utilized for safety and efficacy drug screening, providing novel possibilities for pre-clinical assessment of compound effects.

Ncyte cardiomyocytes are fully functional hiPSC-derived ventricular-like cardiomyocytes derived using our 3D bioreactor technology, that recapitulate healthy human cardiac biology and function. Their relatively slow beat rate enables pacing for electrophysiological research. They offer a valuable cell model for cardiotoxicity testing, drug screening and target validation, as well as for metabolism studies, calcium-imaging and electrophysiology applications.

Product data

Heatmap showing cell activity of ventricular cardiomyocytes

Cells were plated and analyzed using the Axion Maestro™ MEA system. Heat plots of
depolarization peak amplitudes show ~100% coverage of electrodes.