Acute Cardiac Safety - MEA Analysis

Study the cardiac safety profile of your compounds at an early stage of drug development. Ncardia’s in-house Acute Cardiac Safety service provides you with acute cardiac safety profiles of your test compounds, based on the electrophysiology of fully functional and validated human iPSC-derived cardiomyocytes.

What are the benefits?

Fully functional model
Proven ion channel modulating effects of CiPA-reference compounds

Reproducible results
Use of fully validated and quality controlled cardiomyocytes

Label-free and non-invasive physiological assay system


Ncardia's expertise in MEA assays enables us to study the cardiac safety profile of your compounds at an early stage of drug development, using the Maestro MEA system.

Investigating the electrical activity of human induced pluripotent stem cell-derived cardiomycoytes and their acute response to drugs is part of the Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative*, which aims to refine current ICH guidelines to predict clinical potential for life threatening Torsade de Pointes (TdP) tachyarrhythmia. Ncardia is an official partner of the CiPA initiative and our cardiomyocytes were implemented by different core and non-core test sites.

The acute cardiac safety assessment is performed using pre-plated iPSC-derived cardiomyocytes in the Ncyte Cardioplate Maestro MEA. This guarantees a fully controlled assay plate with high plate-to-plate reproducibility. Combined with with MEA platforms, this provides a highly relevant and predictive in vitro assay platform to study compounds’ cardiac safety profile in drug development.

*CiPA (Comprehensive in Vitro Proarrhythmia Assay) is a project driven by the Health and Environmental Science Institute (HESI) and the FDA.



Would you like to know more about our acute cardiac safety service, or any of our other services?

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