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The Calcium Transients are based on fluorescence-based assays that measure changes of intracellular calcium transient parameters. Since calcium is the interdependent regulator between cardiomyocyte electrophysiology and contraction, compounds affecting ion channels can also affect intracellular calcium transients.
For this assay, the human iPSC-derived cardioymocytes are cultured in standard 96 or 384 well plates and loaded with a calcium sensitive dye. All cardiomyocyte culturing steps, including plate coating, cell seeding and medium refreshment will be performed in a fully automated manner, ensuring high assay reproducibility. Compound effects are assessed on the FDSS/µCell Instrument (Hamamatsu).
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