47 Rue Adrienne Bolland
Vascular endothelial cells form the inner lining of blood vessels and are key for normal physiological functioning of tissues. In healthy conditions, these cells form a delicate barrier for tight regulation of the exchange of nutrients and metabolic waste between the blood circulation and surrounding tissues. Dysregulation of this barrier function leads to edema and ultimately to organ failure, which is considered a major dose-limiting adverse effect of many therapeutics under development.
Our advanced data analysis capabilities enable calculation of time course changes in the barrier function of the cell layer, the degree of constricted flow of current under the cells and the cell membrane capacitance. Such analyses enable discrimination between necrosis and apoptosis, between subtle loss of cell-cell contacts or acute cell death, or the detection of a subtle loss of cell-cell contacts which cannot be assessed when using overall resistance.
Would you like to know more about our Endothelial Barrier Toxicity Assay, or any of our other services?
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