This poster presents Ncardia’s Ncyte® NHP-C vCardiomyocytes, a non-human primate iPSC-derived cardiac model designed to support translational safety research. Using electrophysiological assessments of reference compounds, the study explores how NHP cardiomyocytes respond to drugs with known cardiac effects, providing insights relevant to interpreting differences between in vitro and in vivo findings.
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Characterisation of NHP iPSC-derived ventricular cardiomyocytes, demonstrating ≥97% cardiac troponin T-positive cells and stable spontaneous beating activity.
Acute electrophysiological responses to reference compounds including quinidine, moxifloxacin and BayK8644, measured using multi-electrode array (MEA) technology.
Sub-chronic cardiac effects of sunitinib, doxorubicin and pentamidine, including concentration- and time-dependent changes in field potential duration and beat rate.
Concordance with known in vivo cardiac effects, with 5 of 6 compounds showing responses consistent with predicted in vivo effects, supporting the use of NHP cardiomyocytes in translational cardiac safety investigations.