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Vascular
Endothelial cells

Human iPSC-derived vascular endothelial cells

Vascular endothelial cells are involved in multiple processess including blood flow, vascular permeability or angiogenesis. Our team can manufacture endothelial cells from the iPSC line that best fits your project with a controlled and scalable process. Custom assays can be developed with this fully functional cell model to screen drug-induced effects on endothelial barrier permeability or 3D capillary tube formation.

 

cardiac
Ncardia Vascular Endothelial cells,
Actin filaments (red), VE-cadherin
(green), Nuclei (blue).
Benefits
  • Minimal biological variability
  • Functional and physiologically relevant
  • Highly suitable for in vitro modeling and screening
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Are you interested in utilizing vascular endothelial cells for your drug discovery projects?

Cellular Identity Physiologically Relevant Highly suitable for drug discovery

Vascular endothelial cells generated on-demand display characteristic endothelial cell morphology in culture and express key endothelial markers. As an example, left panel contains a representative FACS analysis of one batch of human iPSC-derived vascular endothelial cells showing double expression of CD144 and CD31. Right panel is a phase contrast image showing endothelial morphology in culture.

Vascular endothelial cells generated on-demand are fully functional and physiologically relevant. The cells form endothelial barriers in vitro, and our scientists can assess drug-induced effects on endothelial barrier permeability and angiogenesis with this iPSC-derived cell model.

The figure shows barrier resistance measured at 4 kHz over time using ECISTM (Applied Biophysics).

Vascular endothelial cells generated on-demand are highly suitable for disease modeling and screening. Our scientific team has extensive experience on multiple assays. As an example, our team can help you determine the effect of a library of compounds on angiogenesis using the sprouting assay.

Dose dependent inhibition angiogenic sprouting by the angiogenesis inhibitor Sunitinib
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Questions about our cell models?

Our work centers on a simple yet powerful premise: 
When we combine deep iPSC knowledge, broad assay capabilities and a demonstrated ability to integrate the biology of human diseases into preclinical research, we can help drug developers make critical decisions earlier and with more confidence.