This poster presents Ncardia’s suite of human iPSC-derived neuronal assays designed to model key protein aggregation pathologies across Parkinson’s disease, Alzheimer’s disease, and ALS
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How hiPSC-derived neuronal co-cultures model α-synuclein phosphorylation and aggregation following PFF treatment, with quantifiable readouts suitable for screening
Tau overexpression and chronic PFF exposure strategies that induce misfolded, phosphorylated and insoluble Tau species relevant to Alzheimer’s pathology
CRISPR-engineered TDP-43 mutant motor neurons that reproduce cytoplasmic mislocalization, aggregation, STMN2 downregulation and truncated STMN2 formation
Fully automated, scalable assay formats with robust performance metrics, enabling high-throughput evaluation of aggregation-targeting therapeutics across multiple neurodegenerative indications
Whether you are exploring early aggregation biology or advancing candidates into structured screening cascades, Ncardia’s iPSC-based proteinopathy models provide a reproducible, human-relevant platform for mechanism-driven drug discovery.