This poster presents Ncardia’s automated platform for generating human iPSC-derived 3D cardiac microtissues designed for physiologically relevant and scalable cardiac screening.
The system combines ventricular cardiomyocytes, endothelial cells, and cardiac fibroblasts to create multicellular cardiac tissues suitable for high-throughput calcium transient assays and disease modeling
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A robotic workflow that assembles and maintains cardiac microtissues in 384-well format, enabling scalable high-throughput screening
Calcium transient assays capturing pharmacological responses to compounds such as isoproterenol and nifedipine, demonstrating physiologically relevant cardiac readouts
Modeling of ischemia–reperfusion physiology through real-time oxygen consumption measurements in cardiac microtissues
Disease modeling using CPVT iPSC-derived microtissues, supporting automated screening of ~2,000 compounds with a median Z′-factor of 0.67 and 97 identified hits
If you are scaling cardiac safety or efficacy screening, how well do your current models balance physiological relevance with true high-throughput performance?