Skip to content

Scientific poster: Development and characterization of human iPSC-derived 3D neurospheres for disease modeling and drug discovery

Ncardia author image

By Ncardia Stem Cell Experts

Induced pluripotent stem cells (iPSCs) can be differentiated and culture to generate
iPSC-derived 3D neurospheres to better recapitulate the biology, morphology and molecular
dynamics observed in vivo. Additionally, these models can be developed from patient-derived
iPSCs, thus increasing their relevance and predictability.

Here we describe our iPSC platform for cell differentiation at high volumes of Ncyte® Astrocytes
and Ncyte ® Cortical neurons and how we used them to develop 3D neurospheres amenable for
high-throughput screening. 

This assay platform shows promise in:

- Modeling in vitro relevant neurodegenerative diseases like Alzheimer's and Parkinson's disease.

- Performing with high robustness to be integrated in drug screening

- Protocol can be easily adapted to patient derived iPSC lines for disease modeling, target identification and screening to support you through your drug discovery process

MPS poster

Download the poster by filling the form below: