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Ncyte® GABAergic Neurons
Human iPSC-derived GABAergic neurons

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Ncyte® GABAergic Neurons are human iPSC-derived inhibitory neurons that develop characteristic neuronal morphology and express key markers of GABAergic neuronal identity.

Designed for CNS drug discovery and disease research, Ncyte® GABAergic Neurons provide a human-relevant model for investigating inhibitory signalling and excitatory/inhibitory balance, with applications in areas including epilepsy, neurodevelopmental disorders and psychiatric research.

Benefits
  • Characterised GABAergic neuronal population
  • Relevant for inhibitory signalling and E/I balance research
  • Suitable for CNS drug discovery and disease modelling
neural
Immonofluorescence staining of Ncyte (R) GABAergic neurons. PVALB (Green), MAP2 (Red), DAPI (Blue)
 
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Looking for a kit that fits your workflow?

Choose from Day 7, Day 14, or Day 28 Ncyte® Neuron Kits, providing the cells and culture components needed for your selected culture period

Product Specifications

Identity markers

>80% TUBB3 and >50% GAD65/67, >50% PVALB among TUBB3 positive cells day 7 post-thaw according to user guide

Size

≥1 million viable cells at thawing

Quality Control

Cell count, Viability, Identity, Mycoplasma

Format

Cryopreserved cells

Donor

Female

Reprogramming method

Ectopic expression of reprogramming factors using episomal vector

Shipping conditions

Dry shipper, -180°C to -135°C, supplements on dry ice

Storage conditions

Vapour phase of liquid nitrogen

Supplied with

Required supplements and media for initial culture according to the Ncyte® GABAergic Neurons User Guide.

Technical Data

Cellular Identity Physiologically Relevant Highly suitable for drug discovery

Ncyte® GABAergic Neurons develop characteristic neuronal morphology and extensive neurite growth following thawing and culture.

GABAergic neuronal identity is demonstrated through expression of neuronal and subtype-associated markers, including TUBB3, PVALB and GAD1.

Differentiated neurons can be observed from Day 1–2 post-thaw. For more mature neuronal morphology, culture until at least Day 7 is recommended.

Immunofluorescence staining of Ncyte® GABAergic Neurons demonstrates expression of TUBB3and PVALB.

GABAergic neurons are an important inhibitory component of human neuronal networks and contribute to the regulation of excitatory/inhibitory balance in the central nervous system.

Ncyte® GABAergic Neurons express GABAergic neuron-associated markers including PVALB and GAD1, supporting their use as a human neuronal model for studying inhibitory neuronal biology.

This makes the cells relevant for research into biological mechanisms where altered inhibitory signalling, network balance, epilepsy and seizure modelling are of interest.

Ncyte® GABAergic Neurons are highly suitable for studies of inhibitory signalling, excitatory/inhibitory balance and disease modelling of CNS disorders where altered GABAergic function plays an important role.

They can support research in areas including epilepsy, neurodevelopmental disorders and psychiatric disease, as well as studies of GABAergic pharmacology and interneuron biology.

Our team of neuroscientists is experienced in assay development and functional screening and can help you assess the efficacy and safety of therapeutic candidates in human-relevant neuronal models.

 

Product Information and Applications

Certificates of analysis are available upon request via support@ncardia.com

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Questions about our cell models?

Our work centers on a simple premise: combining deep iPSC knowledge, broad assay capabilities, and human-relevant cellular biology can help drug developers answer critical questions earlier in development. Talk to our scientific team about how Ncyte® Excitatory Neurons could fit your CNS discovery or safety programme.