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Ncyte® Motor Neurons

Human iPSC-derived motor neurons

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Ncyte® Motor Neurons are human iPSC-derived neurons that display characteristic neuronal morphology and express key markers of motor neuron identity.

Designed for CNS drug discovery and disease research, Ncyte® Motor Neurons provide a human-relevant model for studying motor neuron biology and mechanisms relevant to amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA) and neuromuscular disorders.

Benefits
  • Characterised motor neuron population
  • Suitable for functional neuronal studies
  • Relevant for motor neuron disease research
neural

Immunofluorescence staining of Ncyte® Motor Neurons at Day 7 post-thaw.

 
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Looking for a kit that fits your workflow?

Choose from Day 7, Day 14, or Day 28 Ncyte® Neuron Kits, providing the cells and culture components needed for your selected culture period

Product Specifications

Identity markers

TUBB3 and ISL1/2

Size

Approximately 1 × 10⁶ viable cells per vial.

Quality Control

Cell count, Viability, Identity, Mycoplasma

Format

Cryopreserved cells

Donor

Female

Reprogramming method

Ectopic expression of reprogramming factors using episomal vector

Shipping conditions

Dry shipper, -180°C to -135°C, supplements on dry ice

Storage conditions

Vapour phase of liquid nitrogen

Supplied with

Required supplements and media for initial culture according to the Ncyte® Motor Neurons User Guide.

Technical Data

Cellular Identity Highly suitable for drug discovery

Ncyte® Motor Neurons display characteristic neuronal morphology and develop extensive neurite networks in culture. They express key neuronal and motor neuron identity markers, including TUBB3, ISL1/2 and HB9.

Immunofluorescence staining of Ncyte® Motor Neurons at Day 7 post-thaw demonstrates expression of TUBB3 and ISL1/2.

Ncyte® Motor Neurons are highly suitable for drug discovery and disease modelling studies where motor neuron dysfunction plays an important role, including ALS and SMA. Our team of neuroscientists is experienced in assay development and functional screening and can help you assess the efficacy and safety of therapeutic candidates in human-relevant motor neuron models.

Product Information and Applications

Lot Information Sheet is available upon request via support@ncardia.com

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Questions about our cell models?

Our work centers on a simple premise: combining deep iPSC knowledge, broad assay capabilities, and human-relevant cellular biology can help drug developers answer critical questions earlier in development. Talk to our scientific team about how Ncyte® Excitatory Neurons could fit your CNS discovery or safety programme.