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Ncyte® Dopaminergic Neurons

Human iPSC-derived dopaminergic neurons

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Ncyte® Dopaminergic Neurons are human iPSC-derived neurons that develop characteristic neuronal morphology and express key markers of dopaminergic neuronal identity.

Designed for CNS drug discovery and disease research, Ncyte® Dopaminergic Neurons provide a human-relevant model for studying dopaminergic biology and mechanisms relevant to Parkinson’s disease and other disorders involving the dopaminergic system.

Benefits
  • Characterised dopaminergic neuron population
  • Relevant for Parkinson’s disease and dopaminergic-system research
  • Suitable for CNS drug discovery, neuroprotection studies and therapeutic screening
neural

Immonofluorescence staining of Ncyte (R) Dopaminergic neurons. 

 
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Looking for a kit that fits your workflow?

Choose from Day 7, Day 14, or Day 28 Ncyte® Neuron Kits, providing the cells and culture components needed for your selected culture period

Product Specifications

Identity markers

TUBB3, TH and FOXA2

Size

≥1 million viable cells at thawing.

Quality Control

Cell count, Viability, Identity, Mycoplasma

Format

Cryopreserved cells

Donor

Female

Reprogramming method

Ectopic expression of reprogramming factors using episomal vector

Shipping conditions

Dry shipper, -180°C to -135°C, supplements on dry ice

Storage conditions

Vapour phase of liquid nitrogen

Supplied with

Required supplements and media for initial culture according to the Ncyte® Dopaminergic Neurons User Guide.

Technical Data

Cellular Identity Physiologically Relevant Highly suitable for drug discovery

Ncyte® Dopaminergic Neurons display characteristic neuronal morphology and develop extensive neurite networks in culture. They express key neuronal and dopaminergic identity markers including TUBB3, TH and FOXA2, supporting their dopaminergic neuronal identity. Further identification based on additional biomarkers can be performed upon request.

Immunofluorescence staining of Ncyte® Dopaminergic Neurons at Day 7 post-thaw demonstrates expression of vGLUT1, MAP2, DAPI (right) TUBB3 and vGLUT1 (left)

Dopaminergic neurons are a physiologically relevant tool for in vitro studies of human dopaminergic biology. Ncyte® Dopaminergic Neurons express neuronal and dopaminergic markers including TUBB3, TH and FOXA2, supporting their use in human-relevant models for investigating dopaminergic neuronal function and disease-associated mechanisms.

Ncyte® Dopaminergic Neurons are highly suitable for drug discovery and disease modelling studies where dopaminergic neuronal dysfunction plays an important role, particularly Parkinson’s disease. They can support neuroprotection studies, disease-modifying compound screening and neurotoxicity studies. Our team of neuroscientists is experienced in disease modelling, assay development and screening to help you assess the efficacy and safety of therapeutic candidates in human-relevant dopaminergic neuron models.

Product Information and Applications

Lot Information Sheet is available upon request via support@ncardia.com

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Our work centers on a simple premise: combining deep iPSC knowledge, broad assay capabilities, and human-relevant cellular biology can help drug developers answer critical questions earlier in development. Talk to our scientific team about how Ncyte® Excitatory Neurons could fit your CNS discovery or safety programme.