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Ncyte® Sensory Neurons

Human iPSC-derived sensory neurons

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Ncyte® Sensory Neurons are human iPSC-derived peripheral sensory neurons that develop characteristic neuronal morphology and express key markers of sensory and nociceptor identity.

Designed for drug discovery and safety research, Ncyte® Sensory Neurons provide a human-relevant model for studying nociception, sensory neuronal function and mechanisms relevant to chronic and neuropathic pain, peripheral neuropathy and neurotoxicity.

Benefits
  • Characterised sensory neuron polulation
  • Relevant for nociception, chronic pain and peripheral neuropathy research
  • Suitable for analgesic discovery, and neurotoxicity studies
neural

Immonofluorescence staining of Ncyte (R) Sensory neurons. TUBB3 (Red), ISL1/2 (Green), DAPI (Blue)

 
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Looking for a kit that fits your workflow?

Choose from Day 7, Day 14, or Day 28 Ncyte® Neuron Kits, providing the cells and culture components needed for your selected culture period

Product Specifications

Identity markers

TUBB3, BRN3A, ISL1, SCN9A

Size

≥1 million viable cells at thawing.

Quality Control

Cell count, Viability, Identity, Mycoplasma

Format

Cryopreserved cells

Donor

Female

Reprogramming method

Ectopic expression of reprogramming factors using episomal vector

Shipping conditions

Dry shipper, -180°C to -135°C, supplements on dry ice

Storage conditions

Vapour phase of liquid nitrogen

Supplied with

Required supplements and media for initial culture according to the Ncyte® Sensory Neurons User Guide.

Technical Data

Cellular Identity Physiologically Relevant Highly suitable for drug discovery

Ncyte® Sensory Neurons display characteristic neuronal morphology and develop extensive neurite networks in culture. They express key sensory neuronal markers including PRPH, BRN3A, ISL1 and SCN9A, supporting their sensory neuronal identity. Further identification based on additional biomarkers can be performed upon request.

Immunofluorescence staining of Ncyte® Sensory Neurons at Day 7 post-thaw demonstrates expression of vGLUT1, MAP2, DAPI (right) TUBB3 and vGLUT1 (left)

Sensory neurons are a physiologically relevant tool for in vitro studies of human nociception and peripheral sensory biology. Ncyte® Sensory Neurons express markers associated with sensory neuronal identity and nociceptive signalling, including BRN3A, ISL1 and SCN9A. This supports their use in human-relevant models for investigating pain mechanisms, peripheral sensory function and neurotoxicity.

Ncyte® Sensory Neurons are highly suitable for drug discovery and disease modelling studies where nociceptive and peripheral sensory mechanisms play an important role, including chronic pain, neuropathic pain and chemotherapy-induced peripheral neuropathy. They can also support non-opioid analgesic discovery, ion-channel pharmacology and sensory neurotoxicity studies. Our team of neuroscientists is experienced in assay development and screening and can help you assess the efficacy and safety of therapeutic candidates in human-relevant sensory neuron models.

Product Information and Applications

Lot Information Sheet is available upon request via support@ncardia.com

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Our work centers on a simple premise: combining deep iPSC knowledge, broad assay capabilities, and human-relevant cellular biology can help drug developers answer critical questions earlier in development. Talk to our scientific team about how Ncyte® Excitatory Neurons could fit your CNS discovery or safety programme.