hiPSC-Based Functional Screening for CNS RNA Therapeutics

This poster presents Ncardia’s human iPSC-derived neuronal co-culture platform developed to assess efficacy and functional neurotoxicity of antisense oligonucleotides and other CNS-targeted RNA therapeutics

Download it now for a closer look at:

•  A fully automated RT-qPCR workflow in 384-well format with <5% inter-plate variability for robust ASO efficacy assessment 

• High-throughput calcium imaging assays quantifying spontaneous network activity and dose-dependent acute neurotoxicity in hiPSC-derived CNS cultures

• MEA-based electrophysiology capturing ASO-induced changes in firing rate, burst frequency, and network synchrony

• A scalable, automated liquid handling setup enabling reproducible screening from cell seeding to downstream analysis