iPSC Platform for RNA Therapeutics Efficacy & In Vivo Toxicity Poster

By combining automated workflows with physiologically relevant human models, Ncardia’s innovative iPSC-based platforms offer a more predictive, scalable and efficient approach to RNA therapeutic development.

Download it now for a closer look at:

• How Ncardia’s automated RT-qPCR assay achieves high reproducibility in antisense oligonucleotide (ASO) screening across multiple iPSC-derived cell types 
  
• Use of hiPSC-derived cortical neurons and CNS cultures to assess both target knockdown and dose-dependent neurotoxicity 
• Functional insights from calcium transient and MEA assays identifying neuronal excitability and network disruptions 
• How these assays enable early, human-relevant predictions of in vivo toxicity, reducing animal use and improving translational confidence